The Role of Aspirin and Its Derivatives in Enhancing Broiler Health and Performance: A Comprehensive Review"

Abstract

Following restrictions on antibiotic growth promoters (AGPs) in many regions due to their link to the development of microbial resistance. The recent ban on antibiotics in poultry has underscored the urgent need for alternative methods to enhance growth performance in chickens. Various innovative strategies are being explored to address this challenge. Aspirin, known chemically as acetylsalicylic acid, has garnered attention in poultry nutrition, particularly in broiler diets. Its potential benefits include enhancing growth performance, improving feed efficiency, and possibly providing anti-inflammatory effects. This review synthesizes findings from 64 studies conducted between 2015 and 2025 on the impacts of aspirin usage in many animals, especially broiler rations, focusing on growth and development, carcass traits, and health criteria. Review of the literature indicates that the addition of Aspirin to drinking water at concentrations exceeding 200 mg/L was associated with reduced performance and adverse histology in several studies. Conversely, including up to 100 mg/kg of Aspirin in the diet has been demonstrated in several studies to improve performance and decrease the population of Escherichia coli. These effects are especially pronounced under stressful conditions commonly faced in broiler production, such as high stocking densities and heat stress. This review underscores the health advantages and potential uses of Aspirin and its derivatives in broiler nutrition.